Antibiotics are basically medications that refer to antimicrobial drugs. These drugs are used to kill or inhibit the growth of the microbe in vivo without any damage to the host, which allows body’s immune system to eradicate the infection. Antibiotics can be given orally, topically or intravenously. Antibiotics can be naturally sourced or synthetically prepared. On the basis of the range of microbes they affect antibiotics can be classified as narrow spectrum and broad spectrum. Do they affect at localized areas or whole body they can be classified into locally acting and systemic antibiotics.
In old times when people did not discovered that infections are caused by microbes various moulds and plant extracts were used to treat infections. Around 30 years later after this practice the term antibiotics were used. Alexander Fleming accidently discovered penicillin by observing clear zones on a bacterial cultured plate wherever the fungus was grown. After certain trials this antibiotic was produced on large scale.
There are various antibiotics Based on their mechanism of action antibiotics, structural forms and spectrum of activity antibiotics are classified as following types.
- BETA-LACTAMS: Antibiotics of this class contains a 3carbon and 1 nitrogen ring. This ring is highly reactive as they interfere with proteins required by the bacterial cells to form their cell wall. These antibiotics bind to the bacterial PBP’S (penicillin binding proteins) that are used to form the peptidoglycan cell wall of the bacteria. Examples include- penicillin, cephalosporin, monobactams, Carbapenems.
- CEPHALOSPORINS: These antibiotics are similar to penicillin in their structure. These are the most commonly prescribed antibiotics. They are subdivided into generations from 1 to 5 according to their target microorganism. Cephalosporin has various side chains that help them to bind to PBP’S of the bacteria.
- MONOBACTAMS: The beta lactam ring of these antibiotics is not combined to any other ring. Aztreonam is the only commercially available monobactam antibiotic. This is a narrow spectrum antibiotic and can be used to treat urinary tract infections, septicemia, pneumonia.
- CARBAPANEMS: These are basically beta lactamase inhibitors; they show broad spectrum activity against gram negative and gram-positive bacteria. Examples includes: imipenem, Meropenem, ertapenem.
- MACROLIDES: These antibiotics include macro cyclic lactose rings. They are broad spectrum antibiotics and administered to patients that are allergic to penicillin. They effectively inhibit bacterial protein synthesis by binding to the bacterial ribosomes. These antibiotics are administered in low doses as they can lead to inflammation. Examples includes: erythromycin, Azithromycin, Clarithromycin.
- TETRACYCLINES: Members of this class contains 4 hydrocarbon rings therefore named as tetracyclines. They are further classified into generations based on their method of synthesis.1st generations are obtained by biosynthesis, 2nd generations obtained by semi-synthesis and 3rd generations are obtained from total synthesis. These antibiotics target bacterial ribosomes and inhibit protein synthesis in the bacteria. Recommended to patients above 8 years as they have reported teeth discoloration in patients below this age. Examples include: Doxycycline, meclocycline, minocycline.
- QUINOLONES: These antibiotics interfere with bacterial nucleic acids. They target bacterial DNA replication and transcriptions. Their structure originally contained two rings but recent generations of quinolones consist of additional ring that enable them to extend their antimicrobial spectrum. Examples includes: norfloxacin, Ofloxacin, ciproxacin.
- AMINOGLYCOSIDES: The first drug discovered in this class of antibiotics was streptomycin. These are broad spectrum antibiotics. They target ribosomal subunits and inhibit protein synthesis in bacteria. Examples includes: Gentamicin, neomycin, Tobramycin, Amikacin.
- SULPHONAMIDES: These antibiotics inhibit both gram positive and gram negative bacteria. These are widely used in infections like meningitis, septicemia, tonsillitis, bacillary dysentery and UTI’S. Their structure contains a sulphonamide group. They are bacteriostatic antibiotics that is they only inhibit bacterial growth they do not kill them. Examples includes: mefenide, sulfadoxine.
- GLYCOPEPTIDES: These antibiotics are made up of cyclic peptides of seven amino acids. They show antimicrobial activity against gram positive microorganisms by inhibiting their cell wall synthesis. They are further classified into generations. Examples include: Vancomycin, teicoplain, ramoplanin.
- OXAZOLIDINONES: These antibiotics show antimicrobial activity by interfering with bacterial protein synthesis. They bind to the P site of the ribosomal 50s subunit. These are new group of antibiotics that are active against broad spectrum of gram-positive bacteria. They even act against methicillin and Vancomycin resistant staphylococci, penicillin resistant pneumococci. Examples includes: Linezolid, sutezolid, posizolid.
What are the modes of actions of Antibiotics?
Antibiotics are known to kill or inhibit bacterial growth. Antibiotics majorly use bacterial cell organelles or pathways to stop their multiplication and thereby treating the infection. The most common targets of antibiotics are:
- Inhibition of cell wall synthesis: Bacteria are covered by a rigid outer layer called bacterial cell wall. This wall is made up of peptidoglycan. Cell wall protects bacteria from osmotic pressure and hash environment conditions. So in order to maintain their cell wall bacteria must synthesize peptidoglycan which is done by the activity of penicillin binding proteins (PBP’S). Antibiotics inhibit this cross linking of peptidoglycan which eventually destroys the cell wall of the bacteria.
- Breakdown of cell membrane: cell membrane is also known as plasma membrane. This is a semi permeable membrane. It is basically a lipid bilayer that keeps a check on the molecules entering and exiting the cells thus it is very essential for bacteria that their cell membrane functioning is maintained. Antibiotics can destroy the plasma membrane by binding to their lipids.
- Inhibition of nucleic acid synthesis: nucleic acids are essential for proper multiplication and metabolic pathways in the bacterial cells. Antibiotics interfere with nucleic acid synthesis thus inhibiting the DNA replication, and transcription which leads to their essential pathways and functioning of the microbe thus killing them.
- Inhibition of protein synthesis: bacterial proteins are responsible for their structure, metabolic and physiological processes. Proteins are formed by translation of mRNA with the help of ribosomes. Ribosomes are made up of 2 subunits 50s and 30s. Certain antibiotics target on these ribosomal subunits and interfere with protein synthesis thus completely killing the bacteria.
- Blocking key metabolic pathways: some antibiotics mimic the molecules or substrate in the metabolic reactions and thus interfering with essential pathways which are necessary for survival of the bacteria.
What is Antibiotic Sensitivity Test?
Antibiotics affect the growth of infectious microbes in vivo. Infectious agents can be bacteria, protozoa and few parasites. Antibiotics are highly effective to eliminate the infection and to determine which antibiotic is the most effective against a particular bacterial strain; an antibiotic sensitivity test is carried out. Therefore, to choose the best treatment for the patient antibiotic sensitivity test is done. This test also ensures the control of antibiotics in clinical practice thus reducing the risk of prevailing antibiotic resistance. Samples are taken from the patient and microbe identification is done. Then these microbes are allowed to grow on culture plates with antibiotic discs on it. After 24 hrs incubation results are recorded. The antibiotics that will show antimicrobial activity will form a clear zone around its disc and the zone is measured to check minimum inhibition concentration of the antibiotic. Those antibiotics are chosen that have required radius of clear zone. Clear zones are referred to the area where the antibiotics killed bacteria. Also, minimum inhibitory concentrations are measured to check for the lowest concentration of the drug which prevents visible growth of bacteria.
Is antibiotic resistance a major concern?
Antibiotic resistance occurs when the microbe attains ability to defeat the drugs administered to kill or inhibit them. It is one of the biggest threats to global health. This process occurs naturally through multiplication cycles of bacteria but overuse and misuse of antibiotics is accelerating this process. An increasing list of infections such as tuberculosis, pneumonia, blood poisoning, and food borne diseases are becoming harder to treat as antibiotics are becoming less effective due to antibiotic resistance. Immediate change should be implemented in how the antibiotics are prescribed and used.
Antibiotic resistance is of following types :
- Natural resistance
- Acquired resistance
- Cross resistance
- Multi drug resistance
Antibiotic resistance can occur through different mechanisms which include enzymatic inactivation of antibiotics, active pump systems, use of alternative metabolic pathway, and changes in membrane permeability.
How you can Master your antibiotic Pharma Franchise Company Selection?
- CHECK FOR HIGH QUALITY: Quality and efficacy of the antibiotics are very important in order to eliminate the infection completely. A grade Raw material of antibiotics are usually expensive than other grades as there is huge difference in their efficacy. Look for companies that deal in high quality antibiotics. Ask for drug analysis reports from the franchisor to confirm the quality of the antibiotic range.
- ANTIBIOTIC RANGE: Only select companies that are experienced in antibiotics and exhibit wide range antibiotics. Range must include injectables, tablets, capsules, syrups, soft gels, lotions, ointments, and suspensions. Unique and latest antibiotic combinations should be available this will enable you to have an updated product line for your agency. Explore the Antibiotics range offered by Fibovil Pharmaceuticals Pvt Ltd- The best Antibiotic Pharma Franchise Company.
- PRODUCT PACKING: Packaging of the product directly affects its selling ratio in the market. Usually, products with attractive packing and good quality packing material are more in demand. Keep a note of which company offers the most attractive and sturdy packing and them compare all your shortlisted companies and select a company that excels in both quality and packing.
- CERTIFICATIONS AND TRADEMARK REGISTARTIONS: market image of a company is built after years of hard work and extraordinary services. Only reputed companies go for WHO/GMP/GLP/ISO certifications and follow the process to make their products trademark registered. This enables the company to have products worth your trust and helps you to have and exclusive antibiotic range in the market. Let’s take you through Fibovil Pharmaceuticals Pvt Ltd Certifications.
- READ PUBLICATIONS: Pharmaceutical industry is very huge therefore to cope up with the growth trends and market scenarios one definitely needs a thorough research on new product lines, latest combinations, top companies, fraud companies, pharmaceuticals workshops and much more. This research will help you better strategize your business and will increase you profits in the market. Learn More- How to Choose the Best Pharma Franchise Company.
What are new antibiotics combinations available in Antibiotic PCD Company?
Through recent advancements and developments in pharmaceutical sector new combinations of drugs are formulated which are more effective in combating infections and antimicrobial resistance.
- Avibactam/ceftazidime: it is a combination of a cephalosporin and beta-lactamase inhibitor.Majorly used in the treatment of urinary tract infections and complicated intra-abdominal infections. It also acts on strains that are resistant to other antibiotics.
- Ceftolozane/tazobactam: combination of a cephalosporin antibiotic and a beta-lactamase inhibitor. It is used to treat complicated UTI’S.
- Delafloxacin/methicillin-resistant Staphylococcus aureus (MRSA) activity: This combination is used to treat skin and soft tissue infections caused by MRSA. Delafloxacin is basically a Fluoroquinolone antibiotic. It can actively act against MRSA resistant bacteria.
- Meropenem/vaborbactam: it is an effective combination of a carbapenem antibiotic and a beta-lactamase inhibitor. It is administered to treat UTI infections caused by carbapenem-resistant Enterobacteriaceae (CRE).
What are DCGI approved antibiotics available in Pharma Franchise Companies?
Pharmaceutical industry is highly controlled by drug authorities in terms of combinations, MRP, quality, efficacy and distribution of drugs. DCGI (drug controller general of India) is an organization that looks after approving new drugs. Antibiotics are also approved by DCGI for example
- Levofloxacin: Fluoroquinolones antibiotic used to treat, urinary tract infections, skin and soft tissue infections and respiratory tract infections.
- Cefixime: A third-generation cephalosporin antibiotic used to treat respiratory tract infections, urinary tract infections, and sexually transmitted infections.
- Amoxicillin/clavulanic acid: used to treat respiratory tract infections, urinary tract infections, and skin and soft tissue infections. A combination of a penicillin antibiotic and a beta-lactamase inhibitor.
- Meropenem: A carbapenem antibiotic used to treat complicated intra-abdominal infections, skin and soft tissue infections, and urinary tract infections.
- Azithromycin: Macrolides antibiotic used to treat respiratory tract infections, skin and soft tissue infections, and sexually transmitted infections.
What is the role of Pharma Franchise Companies in supply of antibiotics?
With prevalence of infectious diseases it is important to have a strong healthcare system. Advancements are carried out in order to develop more effective antibiotics and combinations that can target broad spectrum of microbes.PCD pharma are franchise companies that allow the distribution and promotion of antibiotics to healthcare providers in different parts of the country. This chain involves doctors, healthcare providers, distributors, clinics and hospitals. This helps in easy accessibility and adequate supply of the drugs to each and every area.PCD companies are coming up with latest drug combinations of antibiotics and also working on existing molecules to serve fine quality antibiotics to target all kinds of microbial infections. With the help of PCD companies’ better service is available of the drugs as they have better understanding of requirements as per area and market. Customer requirements are better acknowledged through PCD network.
Here are some key roles played by PCD franchise in antibiotic distribution:
- Distribution: PCD pharma has a very effective network of distributors and retailers. Particular areas are allotted to distributors where they ensure proper supply and promotion of the antibiotics to, doctors, stockiest, healthcare providers, and customers. This ensures effective distribution of the antibiotics.
- Quality control: pharmaceutical companies ensure that the antibiotics distributed are of high quality and tested for safety and efficacy. Antibiotics certified by drug authorities (WHO/GMP/GLP/DCGI) are marketed. This ensures that quality and efficacy of the antibiotics is maintained.
- Education: PCD companies play an important role in educating healthcare professionals about appropriate dosage, use, indications and safety precautions. They also provide detailed information of frequency of usage, duration of treatment. This ensures that the drugs are distributed effectively and safely.
- Research and development: PCD companies’ deals with latest research-based molecules to offer antibiotics that are highly effective and also target microbes that are antibiotic resistant. This ensures that distributors have latest molecules and are having the product line according to the requirements of the healthcare providers and customers.
You can also be important part of this chain by choosing Pharma Franchise Business as your career option. Tips for -How To Build A Strong Network With Healthcare Providers
Why Fibovil is the perfect destination for Antibiotics Pharma Franchise Company?
Fibovil pharmaceuticals a renowned Pharma franchise company in India. They have created a huge impact in the market through their unique product line, high quality, refined strategies, and distributor friendly business model. They are also the top rank holders as they are a successful PCD franchisor in PAN India. List for Top 10 Pharma Franchise Companies for your reference. Fibovil pharmaceuticals have a robust team that ensures all the operations are carried out as per business requirements. They are massive manufacturers and suppliers of drug range including: generics, gynecology, critical care cardiac diabetic, neurology, urology, pulmonology, antibiotics, orthopedics, ophthalmic range and dermatology. Take a tour for all therapeutics Product Range offered by Fibovil Pharmaceuticals Pvt Ltd.
What makes Fibovil different from other Antibiotic PCD Company?
- High quality
- 100% efficacy
- Unique range
- Attractive packing
- Certified and tested products
- Trademark registered products
- Competitive prices
- Pan India service
- Quick delivery
- Updated business models
- Distributor friendly
- Transparency
- Promotional input support
- Marketing support
ANTIBIOTICS WE OFFER
- Amoxicillin
- Doxycycline
- Cephalexin
- Ciprofloxacin
- Clindamycin
- Metronidazole
- Azithromycin
- Clarithromycin
- Sultamycin
- Erythromycin
- Levofloxacin
- Cefpodoxime
- Cefixime
- Gentamycin
- Cefoperazone
- Ceftriaxone
- Imipenum
- Amikacin
- Cefepime
- Ceftazidime
- Linezolid
- Fusidic acid
- Muprocin
- Penicillin
- Neomycin
- Tobramycin
- Streptomycin
- Rifaximin
- Meropenem
- Vancomycin
- Ampicillin
- Colistin
- Gatifloxacin
- Moxifloxacin
What are Antibiotic Forms Are Available at Fibovil Pharmaceuticals?
- TABLETS: These are most common antibiotic form. It is administered orally. For mild to moderate infections these can be prescribed. Fibovil offers a wide range of antibiotic tablets including: amoxicillin, Doxycycline, Cephalexin, ciprofloxacin, Metronidazole, Azithromycin, trimethoprim and much more.
- CAPSULES: These are hard shell capsules which contains powdered ingredients. They are administered orally. They also come in soft shell capsules.
- LIQUID SUSPENSION: antibiotics are formulated in liquid forms for especially children or patients those have difficulty in swallowing the tablets or capsules.
- TOPICAL CREAMS/OINTMENTS/LOTIONS: these formulations are developed for skin infections caused by bacteria. They are regularly applied as per prescription.
- EYE DROPS/EAR DROPS: antibiotics are formulated in drop forms to treat eye and ear infections. These are applied in the eyes and ears. These are majorly prescribed by ENT specialist.
- INJECTIONS: Antibiotics are also formulated in injectables. They can be administered intramuscular or intravenous as per condition of the patient. The choice of drug form depends on the severity and condition of the patient. Correct form is important for effective results. Antibiotics should be only taken as per doctor’s prescription and complete course of the medication should be done for elimination of the infection properly.
Have a look at Segment wise Range Product Range available at Fibovil Pharmaceuticals Pvt Ltd
Count on Fibovil Pharmaceuticals Pvt Ltd for high quality therapeutics at best prices. Fibovil is doctor’s first choice of drug for prescription. with years of consistent services Fibovil pharmaceuticals has gained healthcare provider’s trust. We welcome you to work with India’s top PCD Pharma Company. Let’s work together and build a strong network of high-quality drugs all over India and gain wings to be the best drug providers globally. We will be happy to assist you in case you need more information in this regard. Please feel free to reach us at:-
Contact No: 8708402647
Email: info@fibovil.com
WhatsApp: https://wa.me/918708402647